Relationship with one's brother who has left home to marry someone he wishes

Q: My youngest brother (on many occasions in the past) disobeyed and disrespected my parents because of a girl he wishes to marry. It has gone to the extent that he has packed up his things and left home. He is now planning to marry this girl. We have been told to just let him be. In the process my parents have became very ill and decided to leave their residential home to not be present when the wedding takes place. After he marries this girl, what is our role (according to Islam) in terms of our relationship with him and his wife?

Marrying a person who has changed his gender

Q: I have been a resident in a foreign country for about 10 years. 2 years ago I met a woman who is completely feminine in nature. As time passed our relationship grew stronger. I wanted her to marry me and convert to Islam. She showed interest in doing so but the real problem is that she was born male by gender, and at the age of 21 she had her gender change operation and removed all the male sexual organs with female body parts. Now she is a women in all ways. There is no going back for her. She is supposed to be a women for the rest of her life. My question is, is there a possibility that a Muslim can still marry her given her circumstances , otherwise we know that to have gay/sexual relations with a man is a despicable sin. Please suggest me what to do.

Omitting Salaah

Q: I suffer from a sever depersonalisation disorder. It prevents me from praying with reverence. I want to pray and I am now trying to memorize as much as I can of the holy Quran. I am so sad I want to pray but I can't feel that while I am praying I am standing between in front of Allah Ta'ala. I have been struggling with it for 7 years and I always make dua' and do everything I can to stop it from letting me live a normal life. I want to know what should I do? Am I being a bad Muslim because I keep skipping prayers?